Physiologically based pharmacokinetic modeling of nanoceria systemic distribution in rats suggests dose- and route-dependent biokinetics
نویسندگان
چکیده
منابع مشابه
Physiologically based pharmacokinetic modeling of cyclotrimethylenetrinitramine in male rats.
A physiologically based pharmacokinetic (PBPK) model for simulating the kinetics of cyclotrimethylene trinitramine (RDX) in male rats was developed. The model consisted of five compartments interconnected by systemic circulation. The tissue uptake of RDX was described as a perfusion-limited process whereas hepatic clearance and gastrointestinal absorption were described as first-order processes...
متن کاملPhysiologically based pharmacokinetic modeling of nanoparticles.
Rapid expansion of nanoparticle research demands new technologies that will enable better interpretation of experimental data and assistance in the rational design of future nanoparticles. The use of physiologically based pharmacokinetic (PBPK) models may serve as powerful tools to meet these needs. PBPK models have been successfully applied for the study of the absorption, distribution, metabo...
متن کاملApplication of a multi-route physiologically based pharmacokinetic model for manganese to evaluate dose-dependent neurological effects in monkeys.
Manganese (Mn) is an essential element that is neurotoxic under certain exposure conditions. Monkeys and humans exposed to Mn develop similar neurological effects; thus, an improved understanding of the dose-response relationship seen in nonhuman primates could inform the human health risk assessment for this essential metal. A previous analysis of this dose-response relationship in experimenta...
متن کاملPhysiologically Based Pharmacokinetic Modeling Suggests Limited Drug–Drug Interaction Between Clopidogrel and Dasabuvir
Dasabuvir, a nonnucleoside NS5B polymerase inhibitor, is a sensitive substrate of cytochrome P450 (CYP) 2C8 with a potential for drug-drug interaction (DDI) with clopidogrel. A physiologically based pharmacokinetic (PBPK) model was developed for dasabuvir to evaluate the DDI potential with clopidogrel, the acyl-β-D glucuronide metabolite of which has been reported as a strong mechanism-based in...
متن کاملInterspecies extrapolation by physiologically based pharmacokinetic modeling
Recently, Christoph Thiel and colleagues from Aachen University published an improved physiologically based pharmacoki-netik modeling (PBPK) technique for mouse to human extrapolation (Thiel et al., 2015). This publication will be awarded by the Ebert Prize 2016 of the American Pharmacist Association, which represents the oldest pharmacy award in the United States. The translation of preclinica...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Nanomedicine
سال: 2018
ISSN: 1178-2013
DOI: 10.2147/ijn.s157210